
700 international high-school students livin’ it @Technion


| Prof. Hossam Haick |
| Prof. Hossam Haick |
Date: 15/08/2011
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The European Society of Cardiology (ESC) honours Prof. Lior Gepstein of the Rappaport Faculty of Medicine with an Outstanding Achievement Award. With this award the ESC Council for Basic Cardiovascular Science annually honours two basic researchers with outstanding accomplishments in the early stage of their career. At the ESC Congress in Paris, Gepstein, together with fellow awardee Thomas Thum of Germany, will each receive an honorary plaque and 3,000 Euros.
The European Society of Cardiology represents over 62,000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe. Stem Cells with a Heart
A Technion study published in Nature in January 2011 shows the ability of human induced pluripotent stem cells (iPSCs ) to recreate – in a Petri dish – a cardiac disorder known as long QT syndrome, enabling researchers to model the abnormal cardiac function and to identify potential new therapeutic agents.
Led by Prof. Lior Gepstein of the Rappaport Faculty of Medicine, the research team obtained skin cells from a patient known to have long QT syndrome – a disease which affects the heart’s ability to recharge itself after each heartbeat, causing fainting, seizures and even leading to sudden death. The Technion scientists turned the skin cells into iPSCs and then coaxed these all-purpose stem cells to become cardiac cells.
These newly created beating heart cells showed abnormal electrical activity, mimicking that of the patient’s actual heart, and enabling the scientists to test the efficacy of different drugs on the cells.
While some patients acquire the syndrome after taking certain medications, Gepstein’s patient was a 28-year-old woman with an inherited form of the disorder – type-2 LQTS – caused by a single genetic mutation. In this case, the individual cardiac cells derived from iPSCs demonstrated the same long recharging period and arrhythmia common in the hearts of long QT syndrome patients.
The study represents a new paradigm to help scientists learn more about how a disease like long QT syndrome works at the cellular level. Gepstein said that the disease “could be demonstrated and studied at the single-cell or multicellular level, but it doesn’t require an entire organ, which of course we cannot create.”
But it also offers a glimpse at the future of personalized medicine, where a patient’s own cells can be used to determine which treatments might work best – or should be avoided – for a particular condition. Furthermore, since heart biopsies, for example, are hard to obtain, this methodology using iPSCs also offers a novel way to study diseased cells that cannot easily be removed from the body. Researchers around the world are also using iPSCs to study other heart diseases and nervous system disorders such as Parkinson’s disease, Gepstein said.
The research team at the Sohnis and Forman Families Center of Excellence for Stem Cell and Tissue Regeneration Research included Ilanit Itzhaki, Leonid Meizels, Irit Huber, and colleagues.
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Date: 15/08/2011
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The European Society of Cardiology (ESC) honours Prof. Lior Gepstein of the Rappaport Faculty of Medicine with an Outstanding Achievement Award. With this award the ESC Council for Basic Cardiovascular Science annually honours two basic researchers with outstanding accomplishments in the early stage of their career. At the ESC Congress in Paris, Gepstein, together with fellow awardee Thomas Thum of Germany, will each receive an honorary plaque and 3,000 Euros.
The European Society of Cardiology represents over 62,000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe. Stem Cells with a Heart
A Technion study published in Nature in January 2011 shows the ability of human induced pluripotent stem cells (iPSCs ) to recreate – in a Petri dish – a cardiac disorder known as long QT syndrome, enabling researchers to model the abnormal cardiac function and to identify potential new therapeutic agents.
Led by Prof. Lior Gepstein of the Rappaport Faculty of Medicine, the research team obtained skin cells from a patient known to have long QT syndrome – a disease which affects the heart’s ability to recharge itself after each heartbeat, causing fainting, seizures and even leading to sudden death. The Technion scientists turned the skin cells into iPSCs and then coaxed these all-purpose stem cells to become cardiac cells.
These newly created beating heart cells showed abnormal electrical activity, mimicking that of the patient’s actual heart, and enabling the scientists to test the efficacy of different drugs on the cells.
While some patients acquire the syndrome after taking certain medications, Gepstein’s patient was a 28-year-old woman with an inherited form of the disorder – type-2 LQTS – caused by a single genetic mutation. In this case, the individual cardiac cells derived from iPSCs demonstrated the same long recharging period and arrhythmia common in the hearts of long QT syndrome patients.
The study represents a new paradigm to help scientists learn more about how a disease like long QT syndrome works at the cellular level. Gepstein said that the disease “could be demonstrated and studied at the single-cell or multicellular level, but it doesn’t require an entire organ, which of course we cannot create.”
But it also offers a glimpse at the future of personalized medicine, where a patient’s own cells can be used to determine which treatments might work best – or should be avoided – for a particular condition. Furthermore, since heart biopsies, for example, are hard to obtain, this methodology using iPSCs also offers a novel way to study diseased cells that cannot easily be removed from the body. Researchers around the world are also using iPSCs to study other heart diseases and nervous system disorders such as Parkinson’s disease, Gepstein said.
The research team at the Sohnis and Forman Families Center of Excellence for Stem Cell and Tissue Regeneration Research included Ilanit Itzhaki, Leonid Meizels, Irit Huber, and colleagues.
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“One of the central discoveries in biology in the post-genome era is the understanding that the main factors contributing to the differences between organisms (for instance, between mice and men) is not the result of genes,” explains Dr. Roee Amit of the Faculty of Biotechnology and Food Engineering at the Technion, who began his research as part of a post-doctoral fellowship at Caltech. “The origin of this difference is in the algorithm or program that determines when, where and how any gene will be expressed. In the past few years a new picture of the genome is becoming clearer, and as a result, also a model in which the genome is perceived as a complex tool for storage and dissemination of information.”
“This tool will be used to ‘hack’ the control program of real organisms and consequently allow us to ‘write’ new programs – which do not exist in nature – for medical purposes, environmental applications, etc. Synthetic biology is a new branch of life science, which takes a constructive/building approach. It attempts to use biological components to construct new biological systems that do not exist in nature. It forces us to really examine our understanding by requiring us to use what we think we understand in order to create biological functions. It allows us to ask why evolution “locked onto” specific patterns, to imagine and create new biological functions and forces us to work in a multidisciplinary fashion.”

“One of the central discoveries in biology in the post-genome era is the understanding that the main factors contributing to the differences between organisms (for instance, between mice and men) is not the result of genes,” explains Dr. Roee Amit of the Faculty of Biotechnology and Food Engineering at the Technion, who began his research as part of a post-doctoral fellowship at Caltech. “The origin of this difference is in the algorithm or program that determines when, where and how any gene will be expressed. In the past few years a new picture of the genome is becoming clearer, and as a result, also a model in which the genome is perceived as a complex tool for storage and dissemination of information.”
“This tool will be used to ‘hack’ the control program of real organisms and consequently allow us to ‘write’ new programs – which do not exist in nature – for medical purposes, environmental applications, etc. Synthetic biology is a new branch of life science, which takes a constructive/building approach. It attempts to use biological components to construct new biological systems that do not exist in nature. It forces us to really examine our understanding by requiring us to use what we think we understand in order to create biological functions. It allows us to ask why evolution “locked onto” specific patterns, to imagine and create new biological functions and forces us to work in a multidisciplinary fashion.”
Technion opens an undergraduate degree program in Bnei Brak in mapping and geo-information
The Technion is opening an undergraduate degree program in Bnei Brak in mapping and geo-information. The studies are intended for young men from the Haredi sector and will be given in the Haredi College of Bnei Brak (Mivchar). The program has been approved by the Council for Higher Education.
“There is a severe lack of trained professionals in every field of civil and environmental engineering,” said the dean of the faculty at the Technion, Prof. Arnon Bentur. “We will help Haredi students in Bnei Brak acquire a profession that guarantees them a respectable career that combines income with a broad vista for advancing in the public and private sectors. The Technion in general, and the Faculty of Civil and Environmental Engineering in particular are exerting great effort to expand our target audiences. These efforts have so far led to the opening of a special Technion study track in the Jerusalem College of Engineering, whose students study for two years in the college’s Jerusalem campus and then complete their studies at the Technion in Haifa. In addition, as a result of these endeavors we now award 100 scholarships annually as part of the “Atidim for Infrastructures” program, with 60% of recipients being young people from the country’s periphery. And in the same way, today, we are reaching out to the Haredi sector. This step represents a unique model that simultaneously responds to two national needs – the first, in the field of engineering and the second, the integration of the Haredi sector into the workforce of the state of Israel. The Center for Mapping of Israel will act to find jobs for graduates of the new program.”
We are talking about a three-year program that will not only award a BA but will also constitute a strong basis for getting a “certified surveyor” license – a much sought after employee. Registration has already begun and the 15-month preparatory program will begin in September. After completing this program, students will study for three years for a BA. Classes will be held at the college in Bnei Brak and will be given by members of the Technion’s Faculty of Civil and Environmental Engineering. Students in the program will be official Technion students even though the classes are being given in Bnei Brak.
The Council for Higher Education’s decision to authorize the Technion to establish the program in Bnei Brak says, in part, that “the recommendation of the Committee for Monitoring Education in the Haredi Sector was given in the framework of the green light given by the Council for Higher Education’s Planning and Budget Committee – to include new programs for Haredi organizational frameworks in the new five year plan, in terms of planning and budgeting.”
The web page of the Haredi College of Bnei Brak says that “Dr. Harav Avrahum Foss, of blessed memory, founder of the Haredi College of Bnei Brak, who gallantly led the vocational revolution of the Haredi sector, initiated the establishment of the college in order to meet the need for appropriate, completely segregated higher education studies for the Haredi public. The great vision of a great founder was to enable thousands of new students to proudly earn a living.”
“As an institution that has been contributing to the state in every field of life since its establishment almost one hundred years ago, the Technion is proud and happy to contribute its part to this national mission – providing a wage-earning profession to the Haredi public,” stressed Technion president, Prof. Peretz Lavie.

